RAPID COMMUNICATION
Long-term effect of niclosamide on inhibition of bacterial leaf blight in rice
| 1 | Department of Plant Science and Research, Institute of Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea |
| 2 | School of Applied Biosciences, Kyungpook National University, Daegu 702-701, Korea |
| 3 | Plant Genomics and Breeding Institute, Seoul National University, Seoul 151-921, Korea |
CORRESPONDING AUTHOR
Hak Soo Seo
Department of Plant Science and Research, Institute of Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea
Department of Plant Science and Research, Institute of Agriculture and Life Sciences, Seoul National University, Seoul 151-921, Korea
Submission date: 2016-07-26
Acceptance date: 2016-10-19
Journal of Plant Protection Research 2016;56(4):323–327
KEYWORDS
TOPICS
ABSTRACT
Bacterial leaf blight is one of the major diseases in rice and affects yields. Thus, various methods have been applied to protect rice from this disease. Here, we show systemic translocation of the human drug niclosamide (5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide) in rice and its long-term effect on prevention of rice leaf blight. The development of Xanthomonas oryzae pv. oryzae-induced rice leaf blight was effectively inhibited in untreated systemic leaves as in niclosamide-treated leaves, although its effect gradually decreased in a time-dependent manner. Time-course examination after niclosamide treatment showed that the niclosamide level was highest after 3 h in non-treated distal leaves, suggesting fast systemic movement of niclosamide from the treated
local site to untreated distal regions. Our data indicate that niclosamide controls rice leaf blight by its rapid systemic movement and that its effect is maintained for a long time.
CONFLICT OF INTEREST
The authors have declared that no conflict of interests exist.
REFERENCES (26)
1.
Balgi A.D., Fonseca B.D., Donohue E., Tsang T.C., Lajoie P., Proud C.G., Nabi I.R., Roberge M. 2009. Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. PLoS ONE 4 (9): e7124.
2.
Cernadas R.A., Doyle E.L., Niño-Liu D.O., Wilkins K.E., Bancroft T., Wang L., Schmidt C.L., Caldo R., Yang B., White F.F., Nettleton D., Wise R.P., Bogdanove A.J. 2014. Code-assisted discovery of TAL effector targets in bacterial leaf streak of rice reveals contrast with bacterial blight and a novel susceptibility gene. PLoS Pathogens 10 (2): e1003972.
3.
Chand T., Sing N., Sing H., Thind B.S. 1979. Field efficacy of stable bleaching powder to control bacterial blight of rice. International Rice Research Newsletter 4 (4): 12–13.
4.
Chen M., Wang J., Lu J., Bond M.C., Ren X.R., Lyerly H.K., Barak L.S., Chen W. 2009. The anti-helminthic niclosamide inhibits Wnt/Frizzled1 signaling. Biochemistry 48 (43): 10267–10274.
5.
Chithrashree A.C., Udayashankar S., Chandra Nayaka M.S., Reddy M.S., Srinivas C. 2011. Plant growth-promoting rhizobacteria mediate induced systemic resistance in rice against bacterial leaf blight caused by Xanthomonas oryzae p v. oryzae. Biological Control 59 (2): 114–122.
6.
Fonseca B.D., Diering G.H., Bidinosti M.A., Dalal K., Alain T., Balgi A.D., Forestieri R., Nodwell M., Rajadurai C.V., Gunaratnam C., Tee A.R., Duong F., Andersen R.J., Orlowski J., Numata M., Sonenberg N., Roberge M. 2012. Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. Journal of Biological Chemistry 287 (21): 17530–17545.
7.
Gnanamanickam S.S. 2002. Biological Control of Crop Diseases. Marcel Dekker, Inc., New York-Basel, 56 pp.
8.
Goto S., Sasakura-Shimoda F., Yamazaki M., Hayashi N., Suetsugu M., Ochiai H., Takatsuji H. 2016. Development of disease-resistant rice by pathogen-responsive expression of WRKY45. Plant Biotechnology Journal 14 (4): 1127–1138.
9.
Han M., Ryu H., Kim C., Park D.S., Ahn Y.K., Jeon J.S. 2013. OsWRKY30 is a transcription activator that enhances rice resistance to the Xanthomonas oryzae pathovar oryzae. Journal of Plant Biology 56 (4): 258–265.
10.
Hoshi T., Yamada K., Yoshizawa Y., Oh K. 2015. Structure-activity relationship study for fungicidal activity of 1-(4-phenoxy-methyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4-triazole derivatives against rice blast. Journal of Plant Protection Research 55 (4): 383–388.
11.
Iwai T., Seo S., Mitsuhara I., Ohashi Y. 2007. Probenazole-induced accumulation of salicylic acid confers resistance to Magnaporthe grisea in adult rice plants. Plant and Cell Physiology 48 (7): 915–924.
12.
Karthikeyan V., Gnanamanickam S.S. 2011. Induction of systemic resistance in rice to bacterial blight by 1,2,3-benzothiadiazole 7-carbothioic acid-S-methyl ester (BTH) treatments. Archives of Phytopathology and Plant Protection 44 (3): 269–281.
13.
Khan J.A., Siddiq R., Arshad H.M.I., Anwar H.S., Saleem K., Jamil F.F. 2012. Chemical control of bacterial leaf blight of rice caused by Xanthomonas oryzae p v. oryzae. Pakistan Journal of Phytopathology 24 (2): 97–100.
14.
Kim S.I., Song J.T., Jeong J.Y., Seo H.S. 2016. Niclosamide inhibits leaf blight caused by Xanthomonas oryzae in rice. Scientific Reports 6: 21209.
15.
Li Q., Chen F., Sun L., Zang Z., Yang Y., He Z. 2006. Expression profiling of rice genes in early defense responses to blast and bacterial blight pathogens using cDNA microarray. Physiological and Molecular Plant Pathology 68 (1–3): 51–60.
16.
McManus P.S., Stockwell V.O., Sundin G.W., Jones A.L. 2002. Antibiotic use in plant agriculture. Annual Review of Phytopathology 40: 443–465.
17.
Nakayama A., Fukushima S., Goto S., Matsushita A., Shimono M., Sugano S., Jiang C.J., Akagi A., Yamazaki M., Inoue H., Takatsuji H. 2013. Genome-wide identification of WRKY45-regulated genes that mediate benzothiadiazole-induced defense responses in rice. BMC Plant Biology 13: 150.
18.
Peng X., Hu Y., Tang X., Zhou P., Deng X., Wang H., Guo Z. 2012. Constitutive expression of rice WRKY30 gene increases the endogenous jasmonic acid accumulation, PR gene expression and resistance to fungal pathogens in rice. Planta 236 (5): 1485–1498.
19.
Sharma A., Sharma R., Imamura M., Yamakawa M., Machii H. 2000. Transgenic expression of cecropin B, an antibacterial peptide from Bombyx mori, confers enhaced restance to bacterial leaf blight in rice. FEBS Letters 484 (1): 7–11.
20.
Shimono M., Sugano S., Nakayama A., Jiang C.J., Ono K., Toki S., Takatsuji H. 2007. Rice WRKY45 plays a crucial role in benzothiadiazole-inducible blast resistance. Plant Cell 19 (6): 2064–2076.
21.
Singh S., Sidhu J.S., Huang N., Vikal Y., Li Z., Brar D.S., Dhaliwal H.S., Khush G.S. 2001. Pyramiding three bacterial blight resistance genes (xa5, xa13 and Xa21) using marker-assisted selection into indica rice cultivar PR106. Theoretical and Applied Genetics 102 (6): 1011–1015.
22.
Swamy P., Panchbhai A.N., Dodiya P., Naik V., Panchbhai S.D., Zehr U.B., Azhakanandam K., Char B.R. 2006. Evaluation of bacterial blight resistance in rice lines carrying multiple resistance genes and Xa21 transgenic lines. Current Science 90 (6): 818–824.
23.
Weinbach E.C., Garbus J. 1969. Mechanism of action of reagents that uncouple oxidative phosphorylation. Nature 221: 1016–1018.
24.
Wu C.J., Jan J.T., Chen C.M., Hsien H.P., Hwang D.R., Liu H.W., Liu C.Y., Huang H.W., Chen S.C., Hong C.F., Lin R.K., Chao Y.S., Hsu J.T. 2004. Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Antimicrobial Agents and Chemotherapy 48 (7): 2693–2696.
25.
Zainudin N.A.I.M., Razak A.A., Salleh B. 2008. Bakanae disease of rice in Malaysia and Indonesia: Etiology of the causal agent based on morphological, physiological and pathogenicity characteristics. Journal of Plant Protection Research 48 (4): 475–485.
26.
Zhu P.J., Hobson J.P., Southall N., Qiu C., Thomas C.J., Lu J., Inglese J., Zheng W., Leppla S.H., Bugge T.H., Austin C.P., Liu S. 2009. Quantitative high-throughput screening identifies inhibitors of anthrax-induced cell death. Bioorganic and Medicinal Chemistry 17 (14): 5139–5145.
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