ORIGINAL ARTICLE
Structure-activity relationship study for fungicidal activity of 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1H-1,2,4-triazole derivatives against rice blast
 
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Department of Biotechnology, Faculty of Bioresource Sciences, Akita Prefectural University, 241-438, Shimoshinjo Nakano, Akita 010-0195, Japan
CORRESPONDING AUTHOR
Keimei Oh
Department of Biotechnology, Faculty of Bioresource Sciences, Akita Prefectural University, 241-438, Shimoshinjo Nakano, Akita 010-0195, Japan
Submission date: 2015-03-18
Acceptance date: 2015-10-23
 
Journal of Plant Protection Research 2015;55(4):383–388
KEYWORDS
TOPICS
ABSTRACT
To explore new antifungal agents for rice blast control, the antifungal activity of a series of novel 1,2,4-triazole derivatives against Magnaporthe oryzae has been evaluated. The antifungal activity was determined by using in vitro mycelial growth inhibition tests. Among the 19 test compounds, we found that the compound 1-(4-phenoxymethyl-2-phenyl-[1,3]dioxolan-2-ylmethyl)-1 H -1,2,4- triazole (Gj ) displayed potent antifungal activity against M. oryzae. The IC 50 value was found approximately 3.8±0.5 μM and the IC 50 value of propiconazole was found to be approximately 3.7±0.2 μM, respectively. Structure-activity relationship studies on aromatic ring structures provided insight and information about the structural requirements for antifungal activity of this synthetic series against M. oryzae
CONFLICT OF INTEREST
The authors have declared that no conflict of interests exist.
 
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